Anabolic and catabolic pathways involved in the metabolism of macromolecules

Anabolic processes tend toward "building up" organs and tissues . These processes produce growth and differentiation of cells and increase in body size, a process that involves synthesis of complex molecules . Examples of anabolic processes include the growth and mineralization of bone and increases in muscle mass. Endocrinologists have traditionally classified hormones as anabolic or catabolic, depending on which part of metabolism they stimulate. The classic anabolic hormones are the anabolic steroids , which stimulate protein synthesis, muscle growth, and insulin . [3] The balance between anabolism and catabolism is also regulated by circadian rhythms , with processes such as glucose metabolism fluctuating to match an animal's normal periods of activity throughout the day. [4]

Children are too fragile and under-formed; their bodies cannot endure the dramatic changes these hormones will invoke.
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A very typical case of severe cholestasis due to anabolic steroid use.  Because the steroids were being used without medical supervision, the dose and actual duration of use of each preparation was unclear, but cholestasis usually arises within 4 to 12 weeks of starting a C-17 alkylated androgenic steroid.  The jaundice can be severe and prolonged and accompanied by severe pruritus and marked weight loss.  The serum enzymes are typically minimally elevated except for a short period immediately after stopping therapy.  The pattern of enzyme elevations can be hepatocellular, cholestatic or mixed.  Liver biopsy shows a “bland” cholestasis with minimal inflammation and hepatocellular necrosis.  Ma Huang has also been implicated in cases of drug induced liver injury, but is associated with an acute hepatocellular pattern of injury.

Anabolic and catabolic pathways involved in the metabolism of macromolecules

anabolic and catabolic pathways involved in the metabolism of macromolecules

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anabolic and catabolic pathways involved in the metabolism of macromoleculesanabolic and catabolic pathways involved in the metabolism of macromoleculesanabolic and catabolic pathways involved in the metabolism of macromoleculesanabolic and catabolic pathways involved in the metabolism of macromoleculesanabolic and catabolic pathways involved in the metabolism of macromolecules

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