But it does point out that increasing AMPk in muscle while decreasing it in the brain is possible and future drugs or nutrient compounds may allow us to get the best of both worlds. Unfortunately, there is still the issue of muscle loss due to the inhibition of protein synthesis that would occur with chronic muscular activation of AMPk. At this point, I have no idea how to sidestep that. Would sufficient amounts of protein, BCAA or even just leucine be sufficient to activate mTOR against the inhibition occurring due to AMPk? Or would another drug or nutrient be required to prevent muscle loss against chronic AMPk activation. At this point, it’s all speculation; hopefully more research will help to answer these questions.