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Pertussis, the “90 day cough,” is problematic. In those older than 2 years, it only responds to treatment with antibiotics in the first 5 days of infection, up to 14 days if you read some sources who readily admit they are stretching the treatment window. From Hopkins: “However, once the paroxysmal stage has begun, antimicrobial therapy has
little effect on the course of illness and is indicated primarily to
limit the spread of the organism to others. Patients are no longer
infectious after 5 days of therapy.” Similarly,”According to the 2001 guidelines of the American College of Physicians for the treatment of uncomplicated acute bronchitis, antibiotic treatment is “not recommended, regardless of duration of cough.”