A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps ; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs. Because cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, CELEBREX is contraindicated in patients with this form of aspirin sensitivity [see CONTRAINDICATIONS ]. When CELEBREX is used in patients with preexisting asthma (without known aspirin sensitivity), monitor patients for changes in the signs and symptoms of asthma.
This element is insidiously toxic with chronic accumulations affecting renal function , pulmonary and cardiovascular tissues , bone , and the peripheral nervous system . Without intervention, the biological half-life of Cadmium in humans exceeds 20 years ( Harrison’s Principles of Internal Medicine , 13th ed, pp 2463-64). Chronic manifestations associated with this degree of Cadmium excess include: hypertension, weight loss, microcytic-hypochromic anemia, lymphocytosis, proteinuria with wasting of beta2 microglobulin, emphysema and pulmonary fibrosis (if inhalation was a route of contamination), atherosclerosis, steomalacia and lumbar pain, and peripheral neuropathy. Acute inhalation of Cadmium dusts, fumes or soluble salts may produce cough, pneumonitis and fatigue . Manifestations of Cadmium toxicity may be lessened or delayed by an individual’s protective and detoxication capacities. Zinc and vitamin E are protective; metallothionein and glutathione bind Cadmium and help detoxify itinitially. Smoking can be a source for as much as mcg Cadmium per cigarette (HEW Pub. No. NIOSH 76-1 92, US Govt. Printing Ofc., 1976). Some medical authorities consider Cadmium to be a carcinogen for lung cancer ( Harrison’s Principles , 13th ed, op. cit. pp 2463). Other occupational or environmental sources include: mining and smelting activities, pigments and paints, electroplating, electroplated parts (., nuts and bolts), batteries (Ni-Cd), plastics and synthetic rubber, photographic and engraving processes, old drums from some copy machines, photoconductors and photovoltaic cells, and some alloys used in soldering and brazing . “Cadmium Red” as used in dental acrylics (dentures) could be a significant source of exposure for those making dentures or dentists/dental techs making fine- tune adjustments (grinding) to dentures chair side. Cadmium- free acrylic dentures are now available. Depending upon the extent of net retention of Cadmium elevated urine Cadmium may occur after administration of EDTA, and to a much lesser extent DMPS, DMSA, or D-penicillamine. Blood Cadmium measurement may not be indicative ( Harrison’s Principles of Internal Medicine , 13th ed., pp 2463).
Following is a list of modified CIGY terms that reflect treatment-emergent adverse events reported by patients treated with Klonopin at multiple doses during clinical trials. All reported events are included except those already listed in Table 3 or elsewhere in labeling, those events for which a drug cause was remote, those event terms which were so general as to be uninformative, and events reported only once and which did not have a substantial probability of being acutely life-threatening. It is important to emphasize that, although the events occurred during treatment with Klonopin, they were not necessarily caused by it.