No steroid is without its drawbacks and that includes oral steroids, which are stressful on your liver, especially with c-17 alpha alkylation ’s which is used to improve absorption of oral steroids. If these chemicals weren’t used the anabolic steroids are often not able to get past the first pass metabolism in the lifer, and therefore the anabolic effects would not be enjoyed. The liver plays a vital role in the body clearing out waste products, and storing important nutrients. On top of the side effects, oral steroids shut down your body’s hormone production. This is why most users will include a steroid, such as, testosterone with the oral steroid, so the body’s testosterone levels are backup.
Most modern steroid enemas are foam based - as the likelihood of someone with colitis being able to retain a water based enema is quite low. These act topically applying the steroid directly to the colon - with only small amounts being absorbed into the bloodstream. This makes side effects less likely. The downside is that they can only reach the descending colon and rectum - so for those with extensive colitis oral steroids may be needed. A combination of Entocort and steroid enemas can provide topical treatment to the majority of the colon - again minimizing side effects. As the two main steroid enemas differ quite greatly I will cover them separately.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.