Secondary neoplasias have developed during cyclophosphamide monotherapy or when this drug was given with other antineoplastic drugs. Patients with hemorrhagic cystitis during therapy or patients with underlying primary myeloproliferative or lymphoproliferative malignancies or disorders appear to be at greatest risk.
In some cases, new neoplasms have been observed several years after exposure to cyclophosphamide.
A controlled longitudinal cohort study of 119 patients with severe rheumatoid arthritis revealed the relative risk of malignancy in patients treated with cyclophosphamide was . Risk was directly proportional to dose. [ Ref ]
Normal Uric acid levels are - mg/dL (female) and - mg/dL (male).
Normal values will vary from laboratory to laboratory.
Also important to blood uric acid levels are purines. Purines are nitrogen-containing compounds, which are made inside the cells of your body (endogenous), or come from outside of your body, from foods containing purine (exogenous). Purine breaks down into uric acid. Increased levels of uric acid from excess purines may accumulate in your tissues, and form crystals. This may cause high uric acid levels in the blood.
Uric acid formation may occur when the blood uric acid level rises above 7 mg/dL. Problems, such as kidney stones, and gout (collection of uric acid crystals in the joints, especially in your toes and fingers), may occur.
One of the worst side effects of THC is anxiety and paranoia. Though small amounts of THC are likely to only induce mild paranoia or social anxiety, edibles and large doses can cause exaggerated side effects (just ask the guy who ate an edible and called 911 because he thought he was dying). THC is known to relieve anxiety in smaller doses and increase it in larger; this is due to its biphasic effects , meaning it can have two opposite effects in high doses. Furthermore, some people are genetically predisposed to experience anxiety with cannabis as a result of brain chemistry.