Singulair vs inhaled steroids

Churg-Strauss syndrome / Delayed / Incidence not known
vasculitis / Delayed / Incidence not known
erythema multiforme / Delayed / Incidence not known
Stevens-Johnson syndrome / Delayed / Incidence not known
toxic epidermal necrolysis / Delayed / Incidence not known
pancreatitis / Delayed / Incidence not known
erythema nodosum / Delayed / Incidence not known
anaphylactoid reactions / Rapid / Incidence not known
angioedema / Rapid / Incidence not known
suicidal ideation / Delayed / Incidence not known
seizures / Delayed / Incidence not known

A double-blind, placebo-controlled RCT of 80 patients has shown that montelukast was more beneficial than placebo in improving forced expiratory volume in one second, improving symptoms, decreasing exacerbations, and providing one more night per week of uninterrupted sleep in patients with aspirin-induced or aspirin-intolerant asthma. 24 Two smaller randomized trials (eight and 40 patients) involving zileuton also support the clinical effectiveness of leukotriene inhibitors in bronchoconstriction induced by aspirin or nonsteroidal anti-inflammatory drugs, as well as for asthma control in patients receiving oral or inhaled steroids. 25 , 26

Whether airway hyperresponsiveness is a symptom of airway inflammation or airway remodeling, or whether it is the cause of long-term loss of lung function, remains controversial. Some investigators have hypothesized that aggressive treatment with anti-inflammatory therapies improves the long-term course of asthma beyond their salutary effects on parameters of asthma control and rates of exacerbation over time. 13 This contention has been supported by an observational study 14 that found long-term exposure to ICS was associated with an attenuation of the accelerated decline in lung function previously reported in asthmatics; more studies are required to substantiate these findings.

Singulair vs inhaled steroids

singulair vs inhaled steroids

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