Guidelines from the American College of Rheumatology conditionally recommend the use of intra-articular corticosteroid injections for treatment of knee osteoarthritis. 51 The duration of pain relief is one to two weeks in most trials, with a few showing improvements lasting three to four weeks. 60 – 63 Research uniformly supports the safety of intra-articular corticosteroid injections for treatment of knee osteoarthritis; however, these studies are limited by lack of histologic data and poor long-term follow-up. 64 A Cochrane review found weak evidence for the use of corticosteroid injections for the treatment of knee rheumatoid arthritis. 52
Certain drugs such as troleandomycin (TAO), erythromycin ( Ery-Tab , EryPed 200), and clarithromycin ( Biaxin ) and ketoconazole ( Nizoral ) can reduce the ability of the liver to metabolize (breakdown) corticosteroids and this may lead to an increase in the levels and side effects of corticosteroids in the body. On the other hand, phenobarbital, ephedrine , phenytoin ( Dilantin ), and rifampin ( Rifadin , Rimactane ) may reduce the blood levels of corticosteroids by increasing the breakdown of corticosteroids by the liver.
Dosage for Kenalog 10 Injection is individualized based on the condition and patient response. Kenalog 10 Injection may interact with aminoglutethimide, birth control pills, hormone replacement therapy, blood thinners, cyclosporine, digoxin, insulin or diabetes medications you take by mouth, isoniazid, rifampin, seizure medication, antibiotics, aspirin, or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications you are taking. Kenalog 10 Injection should be used during pregnancy only if prescribed. This medication may be harmful to a fetus. Infants born to mothers who have received corticosteroids during pregnancy should be observed for signs of hypoadrenalism. This medication can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.